HCID 67281838, compound → HCID 136390989, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-({[1-(tert-butoxycarbonyl)piperidin-4-yl]amino}carbonyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate (60 mg, 0.1 mmol) in chloroform (1.5 mL) was added manganese (IV) oxide (81.4 mg, 0.94 mmol). The reaction mixture was heated to 70° C. and stirred for 3 h. The mixture was cooled to rt, the solid filtered and washed with MeOH to afford methyl 2-({[1-(tert-butoxycarbonyl)piperidin-4-yl]amino}carbonyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate (60 mg, quant). LC-MS: (FA) ES+ 331.

Provenance & Evidence