Hydrochloric Acid → HCID 136380819, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[({7-[(hydroxyamino)carbonyl]-4-oxo-3,4-dihydroquinazolin-2-yl}carbonyl)amino]piperidine-1-carboxylate (45 mg, 0.1 mmol) in methylene chloride (1.5 mL) was added 4.0 M hydrochloric acid in 1,4-dioxane (1.50 mL, 6.0 mmol). The reaction mixture was stirred at rt for 2 h. The solid was filtered and washed with DCM to afford N7-hydroxy-4-oxo-N2-piperidin-4-yl-3,4-dihydroquinazoline-2,7-dicarboxamide.HCl (34 mg, 89%). LC-MS: (FA) ES+ 332; 1H NMR (300 MHz, DMSO) δ 12.42 (s, 1H), 11.55 (s, 1H), 9.28 (s, 1H), 9.11 (d, J=7.7 Hz, 1H), 8.82 (s, 1H), 8.21 (d, J=8.2 Hz, 1H), 8.17 (s, 1H), 7.91 (d, J=8.0 Hz, 1H), 4.13-3.97 (m, 1H), 3.38-3.27 (m, 2H), 3.09-2.95 (m, 2H), 2.02-1.81 (m, 4H).

Provenance & Evidence