HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1616142Generated: October 30, 2026
4-Methoxyphenol → Methyl 2-[3-(4-methoxyphenoxy)propyl]-1-oxo-1,2-dihydroisoquinoline-7-carboxylate
https://huagongshe.com/reaction/1616142
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methoxyphenol | HCID 9015 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-(3-bromopropyl)-1-oxo-1,2-dihydroisoquinoline-7-carboxylate | HCID 67282659 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 2-[3-(4-methoxyphenoxy)propyl]-1-oxo-1,2-dihydroisoquinoline-7-carboxylate | HCID 67281827 | — |
Reaction Steps
To a solution of methyl 2-(3-bromopropyl)-1-oxo-1,2-dihydroisoquinoline-7-carboxylate (80 mg, 0.25 mmol) in DMF (2.5 mL) was added potassium carbonate (68 mg, 0.50 mmol) and 4-methoxyphenol (61 mg, 0.50 mmol). The reaction mixture was heated to 40° C. and stirred overnight. The mixture was then cooled to rt, filtered and concentrated to afford methyl 2-[3-(4-methoxyphenoxy)propyl]-1-oxo-1,2-dihydroisoquinoline-7-carboxylate. LC-MS: (FA) ES+ 368.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08765773B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-cbb0fabcc38f4a2e87f4cf4fa23abad1 |
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| Source note | uspto-grants-2014_07 |
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