Potassium Hydroxide → HCID 86691855, compound

Participants

Reaction Steps

Methyl 3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzoate (15-4) (550 mg, 1.5 mmol, 1.0 eq.) was dissolved in THF (2.5 mL)/MeOH (2.5 mL) and potassium hydroxide (340 mg, 6.0 mmol, 4.0 eq.) was added. The mixture stirred overnight at ambient temperature. Upon completion, the reaction mixture was concentrated and 1N HCl was added. The mixture was then extracted with ethyl acetate and the combined organics were dried over magnesium sulfate, filtered and concentrated to afford 3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl]-4-methylbenzoic acid (55-1) as a white solid. MS (M+H)+: observed=354.0, calculated=354.2.

Provenance & Evidence