反应详情

温度

3 °C

Acetone (260 ml), Succinic acid (12.7 g, 0.107 mol) and water (5 ml) are combined in a flask. The mixture is heated under reflux until total dissolution and then kept at 42° C. Then, the “Solution of solifenacin base” is charged and the mixture is heated to reflux and kept under reflux for 15 minutes. The content is distilled until a final volume of 260 ml. The mixture is cooled slowly until a final temperature of 3° C. and then filtered. The residue is washed with Ethyl acetate (50 ml) at 0/5° C. and is drained for 1 hour. The wet cake is dried in the vacuum oven at 60° C. to give a white solid.

1. temperatureThe mixture is heated
2. temperatureunder reflux until total dissolution
3. customkept at 42° C
4. temperaturethe mixture is heated
5. temperatureto reflux
6. temperatureunder reflux for 15 minutes
7. distillationThe content is distilled until a final volume of 260 ml
8. filtrationfiltered
9. washThe residue is washed with Ethyl acetate (50 ml) at 0/5° C.
10. customThe wet cake is dried in the vacuum oven at 60° C.
11. customto give a white solid