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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1616274Generated: October 31, 2026

Azepane → 2-(Butyloxy)-9-[5-(hexahydro-1H-azepin-1-yl)pentyl]-8-(methyloxy)-9H-purin-6-amine

https://huagongshe.com/reaction/1616274

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAzepaneHCID 8119—
Reactant9-[5-(1-Azetidinyl)pentyl]-2-(butyloxy)-8-(methyloxy)-9H-purin-6-amineHCID 59252625—
Reactant2-(Butyloxy)-9-(5-chloropentyl)-8-(methyloxy)-9H-purin-6-amineHCID 59252636—
Product2-(Butyloxy)-9-[5-(hexahydro-1H-azepin-1-yl)pentyl]-8-(methyloxy)-9H-purin-6-amineHCID 59252592—

Reaction Steps

Prepared similarly to Intermediate 27 from 2-(butyloxy)-9-(5-chloropentyl)-8-(methyloxy)-9H-purin-6-amine and hexahydro-1H-azepine but with sequential purifications by MDAPs using Method A followed by Method E.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765772B2
Source datasetuspto-grants-2014_07
ORD IDord-95622898a6464464ad26278bfe2f60ef
Source noteuspto-grants-2014_07