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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1616281Generated: October 31, 2026

Azepane → 9-[4-(Hexahydro-1H-azepin-yl)butyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine

https://huagongshe.com/reaction/1616281

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAzepaneHCID 8119—
Reactant1-Bromo-4-chlorobutaneHCID 81364—
ReactantN2-Butyl-9-[4-(hexahydro-1H-azepin-1-yl)butyl]-8-(methyloxy)-9H-purine-2,6-diamineHCID 59252652—
ReactantHCID 178448285HCID 178448285—
Product9-[4-(Hexahydro-1H-azepin-yl)butyl]-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amineHCID 59252614—

Reaction Steps

Prepared similarly to Intermediate 36 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1-bromo-4-chlorobutane, and hexahydro-1H-azepine but with three sequential MDAPs using Method B followed by Method A (x2).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765772B2
Source datasetuspto-grants-2014_07
ORD IDord-e3a2d119bff24cba9aaae1337717d43c
Source noteuspto-grants-2014_07