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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1616286Generated: October 26, 2026

1-Bromo-4-chlorobutane → 9-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amine

https://huagongshe.com/reaction/1616286

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-4-chlorobutaneHCID 81364—
ReactantN2-Butyl-9-(4-chlorobutyl)-8-(methyloxy)-9H-purine-2,6-diamineHCID 59252596—
ReactantHCID 178456042HCID 178456042—
SolventCyclohexane ethylacetateHCID 21867204—
Product9-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amineHCID 59252648—

Reaction Steps

Prepared similarly to Intermediate 18 from 8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-1H-purin-6-amine trifluoroacetate and 1-bromo-4-chlorobutane with purification on an aminopropyl (NH2) cartridge using a 0-100% ethyl acetate-cyclohexane gradient.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765772B2
Source datasetuspto-grants-2014_07
ORD IDord-ab7328d5bde34465a59c62dfeb5bca0c
Source noteuspto-grants-2014_07