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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1616291Generated: November 1, 2026

1-Bromo-4-chlorobutane → 9-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpentyl]oxy}-9H-purin-6-amine

https://huagongshe.com/reaction/1616291

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-4-chlorobutaneHCID 81364—
Reactant9-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amineHCID 59252648—
ReactantHCID 178445909HCID 178445909—
Product9-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpentyl]oxy}-9H-purin-6-amineHCID 59252555—

Reaction Steps

Prepared similarly to Intermediate 44 from 8-(methyloxy)-2-{[(1S)-1-methylpentyl]oxy}-1H-purin-6-amine trifluoroacetate and 1-bromo-4-chlorobutane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765772B2
Source datasetuspto-grants-2014_07
ORD IDord-9e7e05bebbec4b3d9fca3c494a834ff8
Source noteuspto-grants-2014_07