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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1616319Generated: October 28, 2026

Methanol → 8-(Methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9-[5-(1-piperidinyl)pentyl]-9H-purin-6-amine

https://huagongshe.com/reaction/1616319

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantPiperidineHCID 8082—
Reactant2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[5-(1-piperidinyl)pentyl]-9H-purin-6-amineHCID 59252574—
Reactant9-(5-Chloropentyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amineHCID 59252598—
SolventDichloromethaneHCID 6344—
Product8-(Methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9-[5-(1-piperidinyl)pentyl]-9H-purin-6-amineHCID 59252646—

Reaction Steps

Prepared similarly to Intermediate 38 from 9-(5-chloropentyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amine and piperidine but with purification on silica using a 0-25% methanol in dichloromethane gradient.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765772B2
Source datasetuspto-grants-2014_07
ORD IDord-86d674d91b9d46baa50788299ac2778b
Source noteuspto-grants-2014_07