4-[4-(2-Nitro-phenyl)-oxazol-2-yl]-butyric acid methyl ester → 4-[4-(2-Amino-phenyl)-oxazol-2-yl]-butyric acid methyl ester

Participants

Reaction Steps

Combine 4-[4-(2-nitro-phenyl)-oxazol-2-yl]-butyric acid methyl ester (3.0 g, 10.3 mmol) with Pd/C (5%, 450 mg) and Pd/black (50 mg) in THF (150 mL) and react with hydrogen (init. 40 psi) in a Parr® apparatus. When reduction is complete, filter the mixture through Celite® and concentrate the filtrate. Drying allows for recovery of crude 4-[4-(2-amino-phenyl)-oxazol-2-yl]-butyric acid methyl ester (2.36 g, 88%). MS (ES): (M+1)+ 261.2 m/z.

Provenance & Evidence