6-[4-(2-Amino-phenyl)-oxazol-2-yl]-hexanoic acid ethyl ester → 6-[4-(2-Amino-phenyl)-oxazol-2-yl]-hexanoic acid

HRID 1616625Notes

Reaction equation

HRID 1616625 reaction equation
NC1C=CC=CC=1C1N=C(CCCC(O)=O)OC=1.C([O:21][C:22](=[O:40])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]1[O:29][CH:30]=[C:31]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=2[NH2:39])[N:32]=1)C>>[NH2:39][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=1[C:31]1[N:32]=[C:28]([CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][C:22]([OH:40])=[O:21])[O:29][CH:30]=1

Participants

3

Reactant 2

HCID 591677896-[4-(2-Amino-phenyl)-oxazol-2-yl]-hexanoic acid ethyl esterHCID 597990014-[4-(2-Amino-phenyl)-oxazol-2-yl]-butyric acid

Product 1

HCID 591678066-[4-(2-Amino-phenyl)-oxazol-2-yl]-hexanoic acidYield 83.1%

Procedure

Using a method similar to the procedure described for the preparation of 4-[4-(2-amino-phenyl)-oxazol-2-yl]-butyric acid; hydrolysis of 6-[4-(2-amino-phenyl)-oxazol-2-yl]-hexanoic acid ethyl ester (2.7 g, 8.9 mmol) gives 6-[4-(2-amino-phenyl)-oxazol-2-yl]-hexanoic acid (2.03 g, 83%). MS (ES): (M+1)+ 274.9 m/z.

Sources & evidence

ORD record
ord-e27ae513224e4e06a6c964bd34acf609
Source dataset
uspto-grants-2014_07
Patent number
US08765796B2

Reaction notes

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