HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[4-(2-Amino-phenyl)-oxazol-2-yl]-propionic acid methyl ester → 3-[4-(2-Amino-phenyl)-oxazol-2-yl]-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[4-(2-Amino-phenyl)-oxazol-2-yl]-propionic acid methyl ester | HCID 59167778 | — |
| Reactant | 4-[4-(2-Amino-phenyl)-oxazol-2-yl]-butyric acid | HCID 59799001 | — |
| Product | 3-[4-(2-Amino-phenyl)-oxazol-2-yl]-propionic acid | HCID 68492670 | 85% |
Reaction Steps
Using a method similar to the procedure described for the preparation of 4-[4-(2-amino-phenyl)-oxazol-2-yl]-butyric acid; hydrolysis of 3-[4-(2-amino-phenyl)-oxazol-2-yl]-propionic acid methyl ester (4.8 g, 19.5 mmol) gives 3-[4-(2-amino-phenyl)-oxazol-2-yl]-propionic acid (3.84 g, 85%) after chromatography over silica gel (MeOH/CH2Cl2). MS (ES): (M+1)+ 233.1 m/z.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765796B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e01c2afc01984b628900d121fc2a4986 |
| Source note | uspto-grants-2014_07 |