HCID 14343212, compound → HCID 12637757, compound

HRID 1616645Notes

Reaction equation

HRID 1616645 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1>[Pd].CO>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1

Participants

4

Reactant 1

HCID 14343212HCID 14343212, compound

Product 1

HCID 12637757HCID 12637757, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-methyl-2-phenylethynyl-pyridine (18.2 g) and 10% palladium on carbon (2.0 g) in methanol (300 mL) is stirred under hydrogen atmosphere (50 psi) at ambient temperature until the triple bond is completely reduced (20 h). The mixture is filtrered and the solvent is removed under reduced pressure.

Workup

  1. custom(20 h)
  2. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-72f6c27bad38409d8d724d40fc0679ac
Source dataset
uspto-grants-2014_07
Patent number
US08765780B2

Reaction notes

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