Trifluoroacetic acid methylene chloride → 2-(3-(4-methoxybenzoyl)thioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid

HRID 1616710Notes

Reaction equation

HRID 1616710 reaction equation
C(O)(C(F)(F)F)=O.C(Cl)Cl.[CH3:11][O:12][C:13]1[CH:42]=[CH:41][C:16]([C:17]([NH:19][C:20](=[S:40])[NH:21][C:22]2[S:32][C:25]3[CH2:26][O:27][C:28]([CH3:31])([CH3:30])[CH2:29][C:24]=3[C:23]=2[C:33]([O:35]C(C)(C)C)=[O:34])=[O:18])=[CH:15][CH:14]=1>>[CH3:11][O:12][C:13]1[CH:42]=[CH:41][C:16]([C:17]([NH:19][C:20](=[S:40])[NH:21][C:22]2[S:32][C:25]3[CH2:26][O:27][C:28]([CH3:31])([CH3:30])[CH2:29][C:24]=3[C:23]=2[C:33]([OH:35])=[O:34])=[O:18])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 86731958tert-Butyl 2-(3-(4-methoxybenzoyl)thioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylate

Product 1

HCID 533019322-(3-(4-methoxybenzoyl)thioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acidYield 46.5%

Procedure

A solution of 40% v/v TFA/DCM (2.5 mL total) was added to tert-butyl 2-(3-(4-methoxybenzoyl)thioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylate (34 mg, 0.071 mmol) and the mixture was stirred at room temperature for 1 h. The volatiles were removed at 30° C. and the material was purified by mass-directed reverse-phase chromatography. 2-(3-(4-Methoxybenzoyl)thioureido)-5,5-dimethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid (14 mg, 0.033 mmol, 46% yield) as a white solid. 1H NMR (500 MHz, DMSO) δ 14.86 (s, 1H), 13.38 (s, 1H), 11.59 (s, 1H), 8.04-7.97 (m, 2H), 7.11-7.03 (m, 2H), 4.65 (s, 2H), 3.86 (s, 3H), 2.73 (s, 2H), 1.22 (s, 6H). 13C NMR (126 MHz, DMSO) δ 174.55, 165.94, 165.28, 163.16, 146.98, 131.01, 129.02, 123.95, 123.75, 116.39, 113.76, 70.12, 58.80, 55.58, 37.25, 26.16. LCMS retention time: 3.264 min; LCMS purity at 214 nm=99%. HRMS m/z calculated for C19H21N2O5S2 [M++1]: 421.0886. found 421.0893. Melting point 213.2° C., decomposition.

Workup

  1. customThe volatiles were removed at 30° C.
  2. customthe material was purified by mass-directed reverse-phase chromatography

Sources & evidence

ORD record
ord-83c37439fff0495fbca8899b3b078132
Source dataset
uspto-grants-2014_07
Patent number
US08765803B1

Reaction notes

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