2,2-Dimethyl-1,3-dioxane-4,6-dione → HCID 59333865, compound

Participants

Reaction Steps

4,5-Dimethoxyanthranilic acid (0.50 g, 2.5 mmol) was added to a solution of Meldrum's acid (0.42 g, 2.9 mmol) in toluene (5.0 mL) and treated according to Procedure 1. 2-[(Carboxyacetyl)amino]-4,5-dimethoxybenzoic acid (0.70 g, 97%) was obtained as a brown solid; δH (400 MHz, DMSO-d6) 3.43 (br s, 2H, CH2), 3.75 (s, 3H, OCH3), 3.79 (s, 3H, OCH3), 7.42 (s, 1H, H3), 8.24 (s, 1H, H6), 11.40 (s, 1H, NH).

Provenance & Evidence