1,4-Dioxane → HCID 53259021, compound

Participants

Reaction Steps

7-(3-Fluoro-benzenesulfonyl)-1,1-dimethyl-3,4-dihydro-1H-benzofuro[2,3-c]pyridine-2-carboxylic acid tert-butyl ester (0.200 g, 0.435 mmol) in 4M HCl in dioxane (5.0 mL, 57.7 mmol) was stirred at rt. After 4 h, the heterogenous mixture was concentrated and triturated with Et2O. The resulting white precipitate was dried under vacuum at 80° C. for 15 h. mp 110-114° C.; MS m/z 360 [M+H]+. 1H-NMR (400 MHz, CDCl3): δ 1.7 (s, 6H), 3.0 (m, 2H), 3.5 (m, 2H), 7.5 (m, 1H), 7.7 (m, 1H), 7.9 (m, 4H), 8.3 (s, 1H), 10.0 (brs, 2H).

Provenance & Evidence