反应详情

Prepared as described for 7-iodo-3,4,5′,6′-tetrahydro-2H,4′H-spiro[1-benzofuro[2,3-c]pyridine-1,3′-pyran] using 2-(6-iodo-benzofuran-3-yl)-ethylamine and 2-methyldihydrofuran-3(2H)-one. The resulting diasteroisomeric mixture was separated using medium pressure liquid chromatography (140 g amine column) eluting with a gradient of EtOAc in hexanes (from 15% to 70% EtOAc).

1. customPrepared
2. customThe resulting diasteroisomeric mixture was separated
3. washeluting with a gradient of EtOAc in hexanes (from 15% to 70% EtOAc)