HCID 67325295, compound → HCID 67325501, compound

HRID 1616899Notes

Reaction equation

HRID 1616899 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:18][CH:10]3[CH2:11][N:12]([C:15](=[O:17])[CH3:16])[CH2:13][CH2:14][CH:9]3[C:8]=2[CH:19]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[O:18][CH:10]3[CH2:11][N:12]([C:15](=[O:17])[CH3:16])[CH2:13][CH2:14][CH:9]3[C:8]=2[CH:19]=1

Participants

4

Reactant 1

HCID 67325295HCID 67325295, compound

Product 1

HCID 67325501HCID 67325501, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 1-(6-nitro-3,4,4a,9a-tetrahydro-1H-benzo[4,5]furo[2,3-c]pyridin-2-yl)-ethanone (600 mg) in MeOH (60 mL) was hydrogenated for 16 h at 10 bar using a H-Cube® instrument with a 70 mm cartridge of 10% Pd—C. The solvent was evaporated to yield 1-(6-amino-3,4,4a,9a-tetrahydro-1H-benzo[4,5]furo[2,3-c]pyridin-2-yl)-ethanone. MS m/z 233 [M+H]+

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-142de8961e88404a89c0975db46b7aac
Source dataset
uspto-grants-2014_07
Patent number
US08765779B2

Reaction notes

Loading…