Sodium Carbonate → HCID 86673695, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(3,4,4a,9a-tetrahydro-1H-benzo[4,5]furo[2,3-c]pyridin-2-yl)-ethanone (825 mg, 3.8 mmol) and thionyl chloride at 0° C., was added dropwise chlorosulfonic acid (1.25 g). The reaction mixture was stirred for 5 min at 0° C., for 2 h at r.t. and poured tehn into ice/H2O (75 g). The solution was brought to pH 7 by adding sodium carbonate and extracted with 75 mL ethyl acetate (2×). The combined organic layers were washed with H2O (2×), separated, and the solvent was evaporated. The resulting sulfonyl chloride was used in the next reaction step without further purification.

Provenance & Evidence