Tert-butyl 7-iodo-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate → Tert-butyl 8-iodo-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate

HRID 1616907Notes

Reaction equation

HRID 1616907 reaction equation
[I:1]C1C=CC2C3CCN(C(OC(C)(C)C)=O)CC3OC=2C=1.CC1(C)C(C)(C)OB([C:30]2[C:35]3[O:36][CH:37]4[CH:42]([C:34]=3[CH:33]=[CH:32][CH:31]=2)[CH2:41][CH2:40][N:39]([C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[CH2:38]4)O1>>[I:1][C:30]1[C:35]2[O:36][CH:37]3[CH:42]([C:34]=2[CH:33]=[CH:32][CH:31]=1)[CH2:41][CH2:40][N:39]([C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[CH2:38]3

Participants

3

Reactant 2

HCID 67325186Tert-butyl 7-iodo-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylateHCID 71009216tert-butyl 8-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate

Product 1

HCID 68304686Tert-butyl 8-iodo-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate

Procedure

Tert-butyl 8-iodo-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate was synthesized as described for tert-butyl 7-iodo-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate P01 starting from tert-butyl 8-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate. MS m/z 402 [M+H]+

Sources & evidence

ORD record
ord-e8e8fd0a1b044d4bb76c0efe27bfd7c7
Source dataset
uspto-grants-2014_07
Patent number
US08765779B2

Reaction notes

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