HCID 67325212, compound → HCID 68305630, compound

HRID 1616915Notes

Reaction equation

HRID 1616915 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH:10]([CH3:21])[C:9]=3[O:22][C:4]=2[CH:3]=1.[I:23]C1C=CC2OC3C(C)NCCC=3C=2C=1>>[I:23][C:7]1[CH:2]=[CH:3][C:4]2[O:22][C:9]3[CH:10]([CH3:21])[N:11]([C:14]([O:16][C:17]([CH3:19])([CH3:20])[CH3:18])=[O:15])[CH2:12][CH2:13][C:8]=3[C:5]=2[CH:6]=1

Participants

3

Reactant 2

HCID 67325212HCID 67325212, compoundHCID 68304689HCID 68304689, compound

Product 1

HCID 68305630HCID 68305630, compound

Procedure

Synthesized as described for tert-butyl 7-iodo-1-methyl-3,4-dihydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate starting from 6-iodo-1-methyl-1,2,3,4-tetrahydro[1]benzofuro[2,3-c]pyridine. MS m/z 414 [M+H]+. 1H-NMR (400 MHz, CDCl3): δ 1.47 (d, J=6.8 Hz, 3H), 1.51 (s, 9H), 2.57 (m, 1H), 2.71 (m, 1H), 3.05 (m, 1H), 4.38 (m, 1H), 5.21 (m, 1H), 7.20 (d, J=8.6 Hz, 1H), 7.51 (dd, J=8.6, 1.8 Hz, 1H), 7.76 (s, 1H).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-74a608537584445593af20f7e318b77d
Source dataset
uspto-grants-2014_07
Patent number
US08765779B2

Reaction notes

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