Tetrahydrofuran → HCID 67323793, compound

Participants

Reaction Conditions

Reaction Steps

To a slurry of Sodium hydride, 60% disp. in mineral oil (7.44 g, 0.186 mol) in Tetrahydrofuran (200 mL, 2 mol) was added and a solution of diethyl cyanomethylphosphonate (30.0 mL, 0.186 mol) in THF (50 mL) slowly, hydrogen was released. After addition and 10 minutes at RT the reaction was cooled at 0° C. and a mixture of (2-acetyl-5-methoxy-phenoxy)-acetic acid ethyl ester (44.6 g, 0.177 mol) in tetrahydrofuran (150 mL) was added dropwise. After 2 hr at 0° C., the reaction was transferred into ice/water and extracted with diethylether. The ether layer was washed with brine, dried, filtered and concentrated. The product was used in the next reaction step without further purification.

Provenance & Evidence