HuagongsheHuagongshe Chemistry Print Report · For research reference only
2'-Hydroxy-3'-methoxyacetophenone → tert-butyl 6-hydroxy-4a-methyl-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2'-Hydroxy-3'-methoxyacetophenone | HCID 95993 | — |
| Reactant | Tert-butyl 7-hydroxy-4a-methyl-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate | HCID 68304817 | — |
| Product | tert-butyl 6-hydroxy-4a-methyl-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate | HCID 68304691 | — |
Reaction Steps
Synthesized as described for tert-butyl 7-hydroxy-4a-methyl-3,4,4a,9a-tetrahydro[1]benzofuro[2,3-c]pyridine-2(1H)-carboxylate and as described in J. Med. Chem., 1989, 32, 2221-2226 starting from 1-(2-hydroxy-3-methoxyphenyl)-ethanone. MS m/z 250 [M-tBu+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765779B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-aa31bad2a93b43c88cd7ae72556ca5c1 |
| Source note | uspto-grants-2014_07 |