Pentylamine → HCID 68415787, compound

HRID 1617120Notes

Reaction equation

HRID 1617120 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH2:10]([NH2:15])[CH2:11][CH2:12][CH2:13][CH3:14]>O1CCOCC1>[CH3:9][C:4]1[N:3]=[C:2]([NH2:1])[N:7]=[C:6]([NH:15][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH:5]=1

Participants

4

Reactant 2

HCID 8060PentylamineHCID 218102-Amino-4-chloro-6-methylpyrimidine

Product 1

HCID 68415787HCID 68415787, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2-Amino-4-chloro-6-methylpyrimidine (10 g) and pentylamine (20 ml) were combined in dioxane (100 mL) and refluxed for 42 h. The solvents were evaporated, the product taken up in DCM, washed with water, sat. sodium bicarbonate solution, brine, dried, and the solvent evaporated to give the subtitle compound 8.3 g.

Workup

  1. temperaturerefluxed for 42 h
  2. customThe solvents were evaporated
  3. washwashed with water, sat. sodium bicarbonate solution, brine
  4. customdried
  5. customthe solvent evaporated

Sources & evidence

ORD record
ord-1d9abdd445c34ba986b626b33b808824
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

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