HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-3-aminoheptan-1-ol → (S)-tert-Butyl 3-(2-amino-4-(1-hydroxyheptan-3-ylamino)-6-methylpyrimidin-5-yl)prop-2-ynylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-3-aminoheptan-1-ol | HCID 55290391 | — |
| Reactant | tert-Butyl 3-(2-amino-4-chloro-6-methylpyrimidin-5-yl)prop-2-ynylcarbamate | HCID 86633394 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | (S)-tert-Butyl 3-(2-amino-4-(1-hydroxyheptan-3-ylamino)-6-methylpyrimidin-5-yl)prop-2-ynylcarbamate | HCID 86633395 | 64.4% |
Reaction Steps
The product from step (vi) (200 mg) and the product from step (v) (177 mg) were combined in butan-1-ol (5 mL) and reacted in a CEM Microwave, at 120° C. for 1 h. The solvents were evaporated, and the crude product was purified by chromatography, eluting with 5% MeOH in EtOAc to afford the subtitle compound 170 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765939B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-c83d8d4b57d643f7827f3c42838cf8d2 |
| Source note | uspto-grants-2014_07 |