Thionyl Chloride → HCID 68749670, compound

HRID 1617148Notes

Reaction equation

HRID 1617148 reaction equation
S(Cl)([Cl:3])=O.[NH2:5][C:6]1[N:11]=[C:10]([CH3:12])[C:9]([CH2:13][C:14]2[CH:15]=[C:16]([CH2:20]O)[CH:17]=[CH:18][CH:19]=2)=[C:8]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[N:7]=1>C(Cl)Cl>[Cl:3][CH2:20][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=1)[CH2:13][C:9]1[C:8]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[N:7][C:6]([NH2:5])=[N:11][C:10]=1[CH3:12]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 66819253HCID 66819253, compound

Product 1

HCID 68749670HCID 68749670, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (0.17 mL) was added to a stirred solution of the product from step (iv) (0.60 g) in DCM (10 mL) at rt. The mixture was stirred for 1 h and the solvent evaporated under reduced pressure to give the subtitle compound as a yellow oil 0.62 g that was used without further purification.

Workup

  1. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-f99ca579bbea40e196bf250da03ac1cd
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

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