反应详情

温度

65 °C

Guanidine carbonate (8.73 g) was added in one portion to a solution of the product from step (i) (14.7 g) in MeOH (200 mL). The resulting mixture was stirred at 65° C. for 16 h and allowed to cool. The precipitate was collected by filtration and suspended in water (50 mL). The solid was collected by filtration, washed with MeOH (20 mL) and EtOAc (20 mL) to give the subtitle compound as a colourless solid 8.60 g that was used without further purification.

1. temperatureto cool
2. filtrationThe precipitate was collected by filtration
3. filtrationThe solid was collected by filtration
4. washwashed with MeOH (20 mL) and EtOAc (20 mL)