反应详情

温度

65 °C

A 5M aqueous solution of potassium hydroxide (3.10 mL) was added to a solution of the product of step (vii) (0.53 g) in MeOH (6 mL). The mixture was stirred at 65° C. for 15 h and allowed to cool. The solvent was evaporated under reduced pressure and the resulting aqueous solution adjusted to pH ˜7 with conc. HCl. The aqueous phase was extracted with DCM and EtOAc, the combined organic phase was evaporated under reduced pressure to give the subtitle compound as a colourless solid 0.547 g.

1. temperatureto cool
2. customThe solvent was evaporated under reduced pressure
3. extractionThe aqueous phase was extracted with DCM and EtOAc
4. customthe combined organic phase was evaporated under reduced pressure