Thionyl Chloride → 4-Chloro-5-(4-(chloromethyl)-2-methoxybenzyl)-6-methylpyrimidin-2-amine

HRID 1617172노트

반응식

HRID 1617172 반응식
S(Cl)([Cl:3])=O.[NH2:5][C:6]1[N:11]=[C:10]([Cl:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]O)=[CH:16][C:15]=2[O:22][CH3:23])=[C:8]([CH3:24])[N:7]=1>C(Cl)Cl>[Cl:12][C:10]1[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][Cl:3])=[CH:16][C:15]=2[O:22][CH3:23])=[C:8]([CH3:24])[N:7]=[C:6]([NH2:5])[N:11]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 86633400(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)methanol

생성물 1

HCID 866334014-Chloro-5-(4-(chloromethyl)-2-methoxybenzyl)-6-methylpyrimidin-2-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Thionyl chloride (0.12 mL) was added to a solution of the product from step (i) (0.39 g) in DCM (10 mL) at 0° C. The reaction mixture was stirred at rt for 1 h and then the solvent was evaporated under reduced pressure to give the subtitle compound (0.40 g) which was used without purification.

후처리

  1. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-23bd45bcba7b431dbad60d591362001a
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765939B2

반응 노트

불러오는 중…