化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1617174作成日：2026年10月25日
(2S)-2-aminopentan-1-ol → (S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile
https://huagongshe.com/reaction/1617174
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (2S)-2-aminopentan-1-ol | HCID 6951248 | — |
| 反応物 | 2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile | HCID 86633402 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | (S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetonitrile | HCID 68955240 | — |
反応手順
(S)-2-Aminopentan-1-ol (0.136 g) was added to a solution of the product from step (iii) in NMP (2 mL). The resulting mixture was stirred at 140° C. for 50 h then diluted with EtOAc and washed with saturated NaHCO3 solution and saturated brine. The organic phase was dried, filtered and evaporated. The crude product was purified by column chromatography, elution gradient 5 to 10% MeOH in DCM to give the subtitle compound, 0.095 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08765939B2 |
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| 出典データセット | uspto-grants-2014_07 |
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| ORD ID | ord-6913b3a48b284ac8ad14246b53620be3 |
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| 出典メモ | uspto-grants-2014_07 |
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