Hydrochloric Acid → HCID 42613159, compound

Participants

Reaction Conditions

Reaction Steps

Concentrated hydrochloric acid (1 mL) was added to a stirred solution of the product from step (i) (0.1 g) in MeOH (2 mL) and the mixture was heated at 70° C. for 2 h. The mixture was allowed to cool and then poured into saturated aqueous NaHCO3 solution (5 mL). The mixture was adjusted to pH ˜7 by adding NaHCO3 and the aqueous was extracted with EtOAc. The combined organic phase was dried, filtered and evaporated. The crude product was purified by RPHPLC to give the title compound, 0.014 g.

Provenance & Evidence