Carbonic acid-guanidine (1:1) → HCID 178493423, compound

HRID 1617199Notes

Reaction equation

HRID 1617199 reaction equation
[OH:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][CH:7]([C:13](=O)[CH3:14])[C:8](OCC)=[O:9])=[C:4]([O:18][CH3:19])[CH:3]=1.C(=O)(O)O.[NH2:24][C:25]([NH2:27])=[NH:26]>CCO>[NH2:27][C:25]1[N:26]=[C:8]([OH:9])[C:7]([CH2:6][C:5]2[CH:16]=[CH:17][C:2]([OH:1])=[CH:3][C:4]=2[O:18][CH3:19])=[C:13]([CH3:14])[N:24]=1

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 68415133Ethyl 2-(4-hydroxy-2-methoxybenzyl)-3-oxobutanoate

Product 1

HCID 178493423HCID 178493423, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of the product from step (ii) (23.35 g) and guanidine carbonate (15.9 g) in EtOH (300 ml) was heated under reflux for 24 h. The mixture was cooled and the solid filtered and washed with EtOH, water, EtOH then diethyl ether and dried to afford the subtitle compound, 11.36 g.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 24 h
  3. temperatureThe mixture was cooled
  4. filtrationthe solid filtered
  5. washwashed with EtOH, water, EtOH
  6. dry with materialdiethyl ether and dried

Sources & evidence

ORD record
ord-95c0ad2605c648febc425fd5a56f843c
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

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