Thionyl Chloride → HCID 178433371, compound

HRID 1617204Notes

Reaction equation

HRID 1617204 reaction equation
S(Cl)([Cl:3])=O.[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]O)=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1>C(Cl)Cl>[ClH:3].[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][Cl:3])=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178433374HCID 178433374, compound

Product 1

HCID 178433371HCID 178433371, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (6 ml) was added to a mixture of the product from step (i) (2.38 g) in DCM (80 ml) and the mixture stirred at rt under nitrogen for 18 h. The mixture was evaporated under reduced pressure to afford the subtitle compound, used crude in next step.

Workup

  1. customThe mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-e5ca24bdfd7244f898f08f6a1175d345
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

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