Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(S)-3-aminohexan-1-ol → (S)-2-(3-((2-Amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-4-fluorophenyl)acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (S)-3-aminohexan-1-ol | HCID 11062353 | — |
| 반응물 | 2-(3-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)-4-fluorophenyl)acetonitrile | HCID 86633410 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | (S)-2-(3-((2-Amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-4-fluorophenyl)acetonitrile | HCID 68956027 | — |
반응 단계
(S)-3-Aminohexan-1-ol (101 mg) was added to a stirred solution of the product from step (iv) (100 mg) in butan-1-ol (2 mL). The reaction was performed in a microwave, at 18° C. for 2 h. The solvent was removed and the crude product was purified using chromatography, to give the subtitle compound, 70 mg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08765939B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-e079734426b64738864890d3027b7891 |
| 출처 메모 | uspto-grants-2014_07 |