HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1617213Generated: October 30, 2026
Phthalimide → (s)-2-(2-Hydroxybutyl)isoindoline-1,3-dione
https://huagongshe.com/reaction/1617213
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | (2S)-2-Ethyloxirane | HCID 10898629 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (s)-2-(2-Hydroxybutyl)isoindoline-1,3-dione | HCID 11424533 | — |
Reaction Steps
To 1,2-Benzenedicarboximide (4.29 g) in DMF (10 ml), (S)-(−)-1,2-epoxybutane (2.1 g) was added followed by K2 CO3 (4.03 g) and heated at 60° C. for 48 h. The reaction was diluted with water, extracted with EtOAc, dried and solvent removed to give the subtitle compound as a white solid, 1.8 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08765939B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-4d5c042ddb8940dfa499ef6269d91d23 |
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| Source note | uspto-grants-2014_07 |
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