HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetramethyltin → 2-Amino-4-methyl-6-(pentylamino)pyrimidine-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetramethyltin | HCID 11661 | — |
| Reactant | 2-Amino-4-chloro-6-(pentylamino)pyrimidine-5-carbaldehyde | HCID 86633406 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Amino-4-methyl-6-(pentylamino)pyrimidine-5-carbaldehyde | HCID 86633407 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To the product from step (i) (20 g) in DMF (200 ml), Pd(PPh3)4 (2 g) was added followed by SnMe4 (20 ml) and the mixture heated at 100° C. for 16 h. The solvent was evaporated and the residue partitoned between EtOAc and brine, the organics were dried and solvent removed. The product was purified by silica chromatography to give the subtitle compound, 14.4 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765939B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-d7d5277a73fa4fdd8b0c24e541551675 |
| Source note | uspto-grants-2014_07 |