反应详情

温度

0 °C

Thionyl chloride (1.359 ml) was added dropwise to a solution of the product from step (i) (4.02 g) in MeOH (50 mL), the resulting suspension was stirred at 0° C. for 10 min then warmed to rt for 18 h. The solvent was evaporated and the residue was diluted with EtOAc washed with sat. NaHCO3 and sat. brine. The organic phase was dried, filtered and evaporated. The crude product was purified by chromatography, to give the subtitle compound as a yellow oil, 1.47 g.

1. temperaturethen warmed to rt for 18 h
2. customThe solvent was evaporated
3. additionthe residue was diluted with EtOAc
4. washwashed with sat. NaHCO3 and sat. brine
5. customThe organic phase was dried
6. filtrationfiltered
7. customevaporated
8. customThe crude product was purified by chromatography