Carbonic acid-guanidine (1:1) → HCID 178499476, compound

HRID 1617232Notes

Reaction equation

C(=O)(O)O.[NH2:5][C:6]([NH2:8])=[NH:7].[CH3:9][O:10][C:11]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([O:30][CH3:31])=[O:29])=[CH:23][C:12]=1[CH2:13][CH:14]([C:20](=O)[CH3:21])[C:15](OCC)=[O:16]>CO>[NH2:7][C:6]1[N:8]=[C:15]([OH:16])[C:14]([CH2:13][C:12]2[CH:23]=[C:24]([CH2:27][C:28]([O:30][CH3:31])=[O:29])[CH:25]=[CH:26][C:11]=2[O:10][CH3:9])=[C:20]([CH3:21])[N:5]=1

Participants

Conditions

Temperature: 50 °C

Procedure

Guanidine carbonate (0.443 g) was added to a solution of the product from step (iii) (0.52 g) in MeOH (10 ml) and stirred at 50° C. for 15 h. The solvent was evaporated and the residue stirred in EtOAc (10 mL) and water (10 mL), the resulting solid was filtered off. Further product was collected by evaporation of the filtrate, the solids were combined to give the subtitle compound as a yellow solid, 0.607 g.

Workup

customThe solvent was evaporated
stirringthe residue stirred in EtOAc (10 mL)
filtrationwater (10 mL), the resulting solid was filtered off
customFurther product was collected by evaporation of the filtrate

Sources & evidence

ORD record: ord-73adad5463464c40b8f836dee9ec9277
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765939B2

Reaction notes

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