Chlorotrimethylsilane → HCID 42613746, compound

HRID 1617244Notes

Reaction equation

HRID 1617244 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C@@H:9]([CH2:12][CH2:13][CH3:14])[CH2:10][OH:11])[C:5]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=[O:24])=[CH:18][C:17]=2[OH:26])=[C:4]([CH3:27])[N:3]=1.[Si](Cl)(C)(C)[CH3:29]>CO>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C@@H:9]([CH2:12][CH2:13][CH3:14])[CH2:10][OH:11])[C:5]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][C:23]([O:25][CH3:29])=[O:24])=[CH:18][C:17]=2[OH:26])=[C:4]([CH3:27])[N:3]=1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 68954538(S)-2-(4-((2-Amino-4-(1-hydroxypentan-2-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetic acid

Product 1

HCID 42613746HCID 42613746, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product from step (i) (120 mg) was dissolved in MeOH (10 mL) and TMS-Cl (0.205 ml) was added and stirred at rt overnight. The crude product was purified by RPHPLC to give the title compound as a white solid, 35 mg.

Workup

  1. customThe crude product was purified by RPHPLC

Sources & evidence

ORD record
ord-c77137f40e62465790bb470d6d8b26f1
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

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