反应详情

温度

100 °C

A mixture of the product of example 81 step (iii) (0.4 g) and (S)-3-aminohexan-1-ol (0.5 g) in butan-1-ol (3 mL) was sealed into a microwave tube. The reaction was performed in the CEM Microwave, at 160° C. and 100 W for 1.5 h. Aq. 5M KOH (iml) was added and the mixture heated at 100° C. for 48 h. The mixture was cooled and the solvent evaporated under reduced pressure. The residue was purified by RPHPLC to give the subtitle compound, 174 mg.

1. customwas sealed into a microwave tube
2. customwas performed in the CEM Microwave, at 160° C.
3. temperatureThe mixture was cooled
4. customthe solvent evaporated under reduced pressure
5. customThe residue was purified by RPHPLC