Thionyl Chloride → HCID 178433377, compound

HRID 1617254Notes

Reaction equation

HRID 1617254 reaction equation
O=S(Cl)[Cl:3].[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20]O)=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1>C(Cl)Cl>[NH2:5][C:6]1[N:11]=[C:10]([OH:12])[C:9]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][Cl:3])=[CH:16][CH:15]=2)=[C:8]([CH3:22])[N:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178433379HCID 178433379, compound

Product 1

HCID 178433377HCID 178433377, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

SOCl2 (20 ml) was added slowly to a stirred mixture of the product from step (i) (6.7 g) in DCM (50 ml) and stirred at rt for 24 h. The solvent was evaporated under reduced pressure to give the title compound, 8.7 g.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-e455ce511d134539b7f685ffc1b6fb91
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

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