Tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate → 2-(1-(2-Methoxyethyl)piperidin-4-ylidene)acetic acid

HRID 1617274Notes

Reaction equation

HRID 1617274 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][C:8](=[CH:11][C:12]([O:14]C)=[O:13])[CH2:7][CH2:6]1.COC(C=C1CCN(C(OC(C)(C)C)=O)CC1)=O>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][C:8](=[CH:11][C:12]([OH:14])=[O:13])[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 10377658Tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylateHCID 59382747Methyl 2-(1-(2-methoxyethyl)piperidin-4-ylidene)acetate

Product 1

HCID 593826602-(1-(2-Methoxyethyl)piperidin-4-ylidene)acetic acid

Procedure

The title compound was prepared following the procedure for the preparation of intermediate 3a except that methyl 2-(1-(2-methoxyethyl)piperidin-4-ylidene)acetate was substituted for tert-butyl 4-((methoxycarbonyl)methylene)piperidine-1-carboxylate.

Sources & evidence

ORD record
ord-ea6b45581aef489b95a73588f7c0dfae
Source dataset
uspto-grants-2014_07
Patent number
US08765946B2

Reaction notes

Loading…