HCID 86719970, compound → HCID 86719971, compound

Participants

Reaction Steps

Add 5% palladium/carbon (15 g; 7.0 mmoles) to a N2 purged flask and add EtOAc (250 mL). Add 3-(methoxymethyl)-6-[1-(1H-pyrazol-5-yl)ethenyl]-3H-1,3-benzothiazol-2-one (29 g, 101 mmoles) as a solution in EtOAc (250 mL). Degas under vacuum and charge with hydrogen via balloon. Stir overnight, evacuate excess hydrogen under pressure and flush with N2. Filter through diatomaceous earth and concentrate to give 3-(methoxymethyl)-6-[1-(1H-pyrazol-5-yl)ethyl]-3H-1,3-benzothiazol-2-one as a thick yellow oil (27 g, 93 mmoles; 92% yield). Material may be carried into the next step without further purification. LCMS (Low) rt=1.73 min., M+1=290.

Provenance & Evidence