反应详情

温度

80 °C

Ethyl 6-(bromomethyl)-2-(trifluoromethyl)pyrimidine-4-carboxylate (1.62 g, 5.17 mmol, from Step A) was dissolved in acetonitrile (15 mL) and sodium acetate (2.8 g, 34 mmol) was added. The mixture was heated to 80° C. for 4 hours, then stood at room temperature overnight. Acetonitrile was removed in vacuo. The residue was partitioned between water and ethyl acetate and the aqueous layer was extracted with two further portions of ethyl acetate. The combined extracts were washed with water, then brine, dried over sodium sulfate, filtered and concentrated. Flash chromatography, eluting with a gradient from 0-60% ethyl acetate/hexane afforded purified product. Yield: 0.95 g (63%); LC-MS: 293.0 (M+H)+. 1H NMR (300 MHz, CDCl3): δ 8.15 (s, 1H), 5.36 (s, 2H), 4.53 (q, 2H), 2.25 (s, 3H), 1.46 (t, 3H).

1. customAcetonitrile was removed in vacuo
2. customThe residue was partitioned between water and ethyl acetate
3. extractionthe aqueous layer was extracted with two further portions of ethyl acetate
4. washThe combined extracts were washed with water
5. dry with materialbrine, dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. washFlash chromatography, eluting with a gradient from 0-60% ethyl acetate/hexane
9. customafforded
10. custompurified product