4-(Methanesulfonyl)phenylboronic acid → HCID 136359966, compound

HRID 1617461Notes

Reaction equation

HRID 1617461 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:9][C:10]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[N:11][OH:12])[CH:5]=[CH:6][CH:7]=1.[CH3:26][S:27]([C:30]1[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=1)(=[O:29])=[O:28]>>[CH3:26][S:27]([C:30]1[CH:35]=[CH:34][C:33]([C:6]2[CH:7]=[CH:2][CH:3]=[C:4]([CH:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[CH3:25])[CH2:9][C:10]([C:13]3[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=3)=[N:11][OH:12])[CH:5]=2)=[CH:32][CH:31]=1)(=[O:29])=[O:28]

Participants

3

Reactant 2

HCID 27343644-(Methanesulfonyl)phenylboronic acidHCID 136359962HCID 136359962, compound

Product 1

HCID 136359966HCID 136359966, compound

Procedure

In analogy to example 22, from 3-(3-bromo-phenyl)-1-pyridin-4-yl-3-o-tolyl-propan-1-one oxime (example 11) and (4-methylsulfonylphenyl)boronic acid was prepared the title compound as a mixture of E and Z isomers (3:1) as a yellow oil, MS (ESI+): m/z=471.1 ([M+H]+).

Sources & evidence

ORD record
ord-d2fedb127fdc4984bd3041b621f2355a
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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