4-Bromobenzyl bromide → 3-(4-Bromo-phenyl)-1-(2,6-dimethyl-pyridin-4-yl)-2-phenyl-propan-1-one

HRID 1617471Notes

Reaction equation

HRID 1617471 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=[O:16])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[C:4]([CH3:17])[N:3]=1.[Br:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Br)=[CH:21][CH:20]=1>>[Br:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:8]([C:6]2[CH:5]=[C:4]([CH3:17])[N:3]=[C:2]([CH3:1])[CH:7]=2)=[O:16])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 685274-Bromobenzyl bromideHCID 666663811-(2,6-Dimethyl-pyridin-4-yl)-2-phenyl-ethanone

Product 1

HCID 666682453-(4-Bromo-phenyl)-1-(2,6-dimethyl-pyridin-4-yl)-2-phenyl-propan-1-one

Procedure

In analogy to example 43, step 1, from 1-(2,6-dimethyl-pyridin-4-yl)-2-phenyl-ethanone and 4-bromobenzylbromide was prepared the title compound as a yellow oil, MS (ESI+): m/z=394.0 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-dde1a79d3b1042fc8b3b7c0063020925
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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