(Pyrimidin-5-yl)boronic acid → HCID 58043435, compound

HRID 1617478Notes

Reaction equation

HRID 1617478 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])[CH2:9]/[C:10](/[C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=2)=[N:11]\[OH:12])=[CH:4][CH:3]=1.[N:28]1[CH:33]=[C:32](B(O)O)[CH:31]=[N:30][CH:29]=1>>[F:19][C:17]1[CH:18]=[C:13](/[C:10](=[N:11]/[OH:12])/[CH2:9][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([C:32]3[CH:33]=[N:28][CH:29]=[N:30][CH:31]=3)=[CH:3][CH:4]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])[CH:14]=[C:15]([F:20])[CH:16]=1

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 58043159HCID 58043159, compound

Product 1

HCID 58043435HCID 58043435, compound

Procedure

In analogy to example 22, from (E)-3-(4-bromo-phenyl)-1-(3,5-difluoro-phenyl)-3-o-tolyl-propan-1-one oxime (example 53) and pyrimidine-5-boronic acid was prepared the title compound as a white foam, MS (ESI+): m/z=430.3 ([M+H]+).

Sources & evidence

ORD record
ord-36d2b508789d407fb9db9c09a0eb318b
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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