HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Iodopyridine → 2-(9H-Fluoren-9-yl)-1-pyridin-4-yl-ethanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Iodopyridine | HCID 609492 | — |
| Edukt | 2-(9H-Fluoren-9-yl)-N-methoxy-N-methyl-acetamide | HCID 86660945 | — |
| Edukt | Butyllithium | HCID 178418339 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-(9H-Fluoren-9-yl)-1-pyridin-4-yl-ethanone | HCID 66666573 | — |
Reaktionsschritte
In analogy to example 55, step 2, from 2-(9H-fluoren-9-yl)-N-methoxy-N-methyl-acetamide and 4-iodopyridine using isopropylmagnesium chloride lithium chloride complex in THF at rt (instead of n-BuLi at −70° C.) was prepared the title compound as yellow oil, MS (ESI+): m/z=286.1 ([M+H]+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08765730B2 |
| Quelldatensatz | uspto-grants-2014_07 |
| ORD ID | ord-9b55fd442b5543129a0136d6f4e36a3a |
| Quellennotiz | uspto-grants-2014_07 |