Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1617513Generated: October 25, 2026

2-Fluoro-4-(methoxycarbonyl)benzeneboronic acid → 2-Fluoro-4'-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid methyl ester

https://huagongshe.com/reaction/1617513

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-4-(methoxycarbonyl)benzeneboronic acidHCID 24824345—
Reactant3-(4-Bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-oneHCID 66668180—
Product2-Fluoro-4'-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid methyl esterHCID 66666683—

Reaction Steps

In analogy to example 74, step 6, from 3-(4-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one (example 74, step 5) and 2-fluoro-4-(methoxycarbonyl)phenylboronic acid was prepared the title compound as a light brown oil, MS (ESI+): m/z=468.1961 ([M+H]+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765730B2
Source datasetuspto-grants-2014_07
ORD IDord-505d367c4e9a47a4bbe0e38af98db6ba
Source noteuspto-grants-2014_07